N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride

Name	CZC-54252
Synonyms	CS-1730 CZC54252 CZC 54252 CZC-54252 CZC 54252 hydrochloride N-(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride
CAS	1191911-27-9

Molecular Formula	C22H25ClN6O4S
Molar Mass	504.99
Density	1.452±0.06 g/cm3(Predicted)
Boling Point	718.1±70.0 °C(Predicted)
Solubility	DMSO: 21 mg/mL
pKa	8.50±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
In vitro study	CZC-54252 inhibits the activity of recombinant human wild-type LRRK2 with an IC 50 ranging from ～1 to ～5 nM. The G2019S mutant is inhibited with an IC 50 ranging from ～2 to ～7 nM in a TF-FRET assay. In addition, they are screened against a kinase panel of 185 kinases and exhibited good selectivity. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 with an EC 50 of ~1 nM and fully reversed to wild-type levels by CZC-54252 at concentration of 1.6 nM.

Last Update：2024-01-02 23:10:35

biological activity	CZC-54252 is an effective LRRK2 inhibitor with IC50 of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2 respectively.
target	TargetValue LRRK2 (WT) (Cell-free say) 1.28 nM LRRK2 (G2019S) (Cell-free say) 1.85 nM
Target	Value
LRRK2 (WT) (Cell-free assay)	1.28 nM
LRRK2 (G2019S) (Cell-free assay)	1.85 nM
in vitro study	CZC-54252 inhibits the activity of recombinant human wild-type LRRK2 with an IC 50 ranging from ~ 1 to ~ 5 nM. The G2019S mutant is inhibited with an IC 50 ranging from ~ 2 to ~ 7 nM in a TF-FRET say. In addition, they are screened against a kinase panel of 185 kinases and exhibited good selectivity. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 with an EC 50 of ~ 1 nM and fully reversed to wild-type levels by CZC-54252 at concentration of 1.6 nM.

Last Update：2024-04-09 15:16:38

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CAS: 1191911-27-9
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Product Name: CZC-54252 Visit Supplier Webpage Request for quotation
CAS: 1191911-27-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride Request for Quotation